Pore Structures for High-Throughput Nanopore Devices

Pore Structures for High-Throughput Nanopore Devices

Blog Article

Nanopore devices are expected to advance the next-generation of nanobiodevices because of their strong sensing and analyzing capabilities for single molecules and bioparticles.However, the device throughputs are not sufficiently high.Although analytes TACTICAL PEN pass through a nanopore by electrophoresis, the electric field gradient is localized inside and around a nanopore structure.

Thus, analytes located far from a nanopore cannot be driven by electrophoresis.Here, we report nanopore structures for high-throughput sensing, namely, inverted pyramid (IP)-shaped nanopore structures.Silicon-based IP-shaped Home nanopore structures create a homogeneous electric field gradient within a nanopore device, indicating that most of the analytes can pass through a nanopore by electrophoresis, even though the analytes are suspended far from the nanopore entrance.

In addition, the nanostructures can be fabricated only by photolithography.The present study suggests a high potential for inverted pyramid shapes to serve as nanopore devices for high-throughput sensing.